Best OTC Choices in Migraine Headache Products

Products that are billed as relieving migraine headaches include extra-strength formulations of familiar pain killers, specialized migraine formulations and those that contain natural ingredients.

All types are represented in Money’s picks for the best over-the-counter migraine remedies. The selections were made by drugs.com, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on Money.com is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Rank
Medication
Active Ingredients
Important Points
#8
Advil Liqui-Gels Ibuprofen
  • Safe for people 12 years and older
  • Can take up to every 4 hours
  • Fast pain or fever relief
  • Can cause stomach upset
#2
Advil Migraine Ibuprofen
  • Capsules
  • Safe for people 18 years and older
  • Taken once a day
#4
Aleve caplets Naproxen
  • Lasts up to 12 hours
  • Tablets
  • Safe for people 12 years and older
  • Can cause stomach upset
#7
BC Powder Aspirin Caffeine
  • Relieves minor aches and pains
  • Safe for people 12 years and older
  • Can take up to every 6 hours
  • Can mix into liquid or sprinkle on tongue
#1
Excedrin Migraine Acetaminophen Aspirin Caffeine
  • Tablets
  • Safe for people 18 years and older
  • Taken once a day
#6
Goody's Headache Powder Acetaminophen Aspirin Caffeine
  • Powder
  • Safe for people 12 years and older
  • Can take every 6 hours
#5
Migralax Vitamin B2 Magnesium Feverfew extract
  • Dietary supplement
  • Capsules
  • May help relieve migraine headaches
#9
Motrin IB Liquid Gels Ibuprofen
  • Safe for people 12 years and older
  • Can take up to every 4 hours
  • Fast pain or fever relief
  • Can cause stomach upset
#3
Tylenol Extra Strength Caplets Acetaminophen
  • Reduces fever and pain
  • Safe to use in people 12 years and older
  • Can take every 6 hours
No results match.
TOP

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.