Best OTC Drugs 2024

Best OTC Choices in Cold Sore Treatments

While you can treat cold sores with prescription antiviral medications, the best OTC options may also shorten how long you’re affected by these annoyances. Here are Money’s picks for the best cold sore treatments. We’ve included information on the picks’ active ingredients along with general notes about efficacy and side effects.

The selections were chosen by drugs.com, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on Money.com is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Rank
Medication
Active Ingredients
Important Points
#1
Abreva Cold Sore Cream Docosanol
  • Cream
  • Must be applied 5 times a day
  • Shortens healing time of cold sores
#8
Blistex Medicated Lip Ointment Camphor Dimethicone Menthol Phenol
  • Safe for people 2 years and older
  • Relieves pain from cold sores
  • Moisturizes lips
  • Lip ointment
#10
Campho-Phenique Cold Sore Treatment Camphorated phenol
  • Gel
  • Safe for people 2 years and older
  • Relieves pain from cold sores
  • Prevents infection
#3
Carmex Multi Symptom Cold Sore Treatment Benzocaine White petrolatum
  • Cream
  • Safe for people 2 years and older
  • Can be applied up to 4 times a day
  • Relieves cold sore pain and dryness
#6
Compeed Cold Sore Patches Hydrocolloid
  • Protects up to 12 hours
  • Patches
  • Comes in portable box
#4
Herpecin-L Lip Balm Dimethicone Meradimate Octisalate Octinoxate Oxybenzone
  • Contains sunscreen
  • Moisturizes
  • Safe for people 12 years and older
  • Lip balm
#2
Orajel Cold Sore Cream Benzocaine White petrolatum
  • Cream
  • Safe for people 2 years and older
  • Can be applied up to 4 times a day
  • Relieves cold sore pain and dryness
#5
Quantum Health Lip Clear Lysine+ Menthol
  • Ointment
  • Safe for people 2 years and older
  • Can use as needed
  • Relieves itching, burning, pain with cold sores
#9
Releev 1 Day Cold Sore Treatment Benzalkonium chloride
  • Safe for people 12 years and older
  • Can use up to 4 times a day
  • Antiseptic
#7
Zilactin Cold Sore Gel Benzyl alcohol
  • Relieves pain up tp to 6 hours
  • Safe for people 2 years and older
  • Gel
No results match.
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Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.