Best OTC Drugs 2024

Best OTC Choices in Expectorants

By loosening up the mucus created by a cold, expectorants aim to make it easier to cough up mucus effectively and clear your throat. Here are Money’s picks for the best expectorants, along with information on their active ingredients and general notes about their efficacy and side effects.

These products are among 16 types of cough, cold and allergy treatments assessed for us by drugs.com, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on Money.com is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Rank
Medication
Active Ingredients
Important Points
#1
Mucinex Guaifenesin
  • Treats congestion
  • Non-drowsy
  • Lasts 12 hours
  • Safe in children 12 years and older
#2
Robitussin Cough + Chest Congestion DM Dextromethorphan, Guaifenesin
  • Relieves cough
  • Treats congestion
  • Safe in children 12 years and older
  • Non-drowsy
#3
Delsym Cough + Chest Congestion Dextromethorphan, Guaifenesin
  • Relieves cough
  • Treats congestion
  • Available as a liquid
  • Safe in children 12 years and older
  • Non-drowsy
#4
Chestal Honey Cough Syrup Antimonium tartaricum, Bryonia, Coccus cacti, Drosera, Ipecacuanha, Pulsatilla, Rumex crispus, Spongia tosta, Sticta pulmonaria
  • Homeopathic
  • Soothes cough and throat
  • 99.99% alcohol free
  • Safe in children 2 years and older
#5
Bronkaid Ephedrine sulfate
  • Improves asthma symptoms
  • Available as tablets
  • Safe in children 12 years and older
  • Non-drowsy
#6
Alka-Seltzer Plus Cough + Chest Congestion Dextromethorphan, Guaifenesin
  • Relieves cough
  • Treats congestion
  • Available as effervescent tablets
  • Safe in children 12 years and older
  • Non-drowsy
#7
Walgreens Mucus Relief ER Guaifenesin
  • Treats congestion
  • Available as tablets
  • Lasts 12 hours
  • Safe in children 12 years and older
  • Non-drowsy
#8
Rite Aid Tussin Mucus + Chest Congestion Guaifenesin
  • Treats congestion
  • Alcohol free
  • Safe in children 12 years and older
  • Non-drowsy
#9
Hyland's Bronchial Cough Rumex crispus, Sanguinaria canadensis, Kali bichromicum
  • Homeopathic
  • Quick-dissolving tablets
  • Natural relief for coughs with mucus
No results match.
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Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.