Best OTC Drugs 2024

Best OTC Choices in Flu Products

Catching influenza — flu — can trigger a collection of unpleasant consequences, from feverishness to aches and pains to a cough, cold and runny nose. Here are Money’s picks for the best products to relieve multiple flu symptoms. We include information on active ingredients and general notes about efficacy and side effects.

These products are among 16 types of cough, cold and allergy treatments assessed for us by drugs.com, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on Money.com is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Rank
Medication
Active Ingredients
Important Points
#1
Tylenol Cold & Flu Severe Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
  • Non-drowsy
  • Reduces fever
  • Relieves cough
  • Improves nasal congestion
  • Available in liquid and caplets
#2
Advil Multi-Symptom Cold & Flu Chlorpheniramine, Phenylephrine, Ibuprofen
  • Can cause drowsiness
  • Reduces fever
  • Improves nasal congestion
  • Reduces sneezing
  • Available as tablets
  • Safe in children 12 years and older
#3
Theraflu Flu Relief Acetaminophen, Dextromethorphan
  • Reduces fever
  • Relieves cough
  • Available in a powder for liquid
  • Safe in children 12 years and older
#4
NyQuil Severe Cold & Flu Acetaminophen, Dextromethorphan, Doxylamine, Phenylephrine
  • Can cause drowsiness
  • Reduces fever
  • Improves nasal congestion
  • Relieves cough
  • Available as liquid and capsules
  • Safe in children 12 years and older
#5
Mucinex Nightshift Cold & Flu Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
  • Relieves sore throat
  • Improves congestion
  • Relieves cough
  • Reduces fever
  • Safe in children 12 years and older
  • Available in a liquid
#6
Robitussin Cough + Chest Congestion DM Dextromethorphan, Guaifenesin
  • Non-drowsy
  • Relieves cough
  • Improves congestion
  • Safe in children 12 years and older
  • Available in a liquid
#7
Vicks DayQuil/NyQuil Combo Nyquil: Acetaminophen, Dextromethorphan, Doxylamine DayQuil: Acetaminophen, Dextromethorphan, Phenylephrine
  • Relieves fever
  • Relieves cough
  • Available in capsules and liquid
  • Safe in children 12 years and older
#8
Oscillococcinum by Boiron Anas barbariae
  • Safe in children 2 years and older
  • Non-drowsy
  • Dissolves under the tongue
#9
Herbion Naturals Elderberry Syrup Elderberry extract
  • Available in a liquid
  • Safe in children 1 year and older
  • Gluten free
No results match.
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Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.