Best OTC Drugs 2024

Best OTC Choices in Lice Treatments

Head-lice medications available over-the-counter without a prescription may kill the invasive pests, some with FDA-approved chemicals. Here are Money’s picks for the best lice treatment, along with data on their active ingredients and general notes about their efficacy and side effects.

The selections were chosen by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Clearlice Natural Lice Treatment Sodium c14-16 olefin sulfonate
  • Must apply for 40 minutes
  • Shampoo and conditioner in one
  • Peppermint scent
Equate Complete Lice Treatment Kit Piperonyl butoxide Pyrethrum extract
  • Contains shampoo, comb-out spray, and home spray
Fairy Tales Lice Good-Bye Survival Kit Urea
  • Contains foam, comb, and conditioning spray
Licefreee! Lice Killing Hair Gel Sodium chloride
  • Kills lice and eggs
  • Chemical-free
  • Homeopathic
LiceMD Pesticide-Free Head Lice Removal Kit Dimethicone
  • Pesticide-free
  • Odor-free
  • Works in 10 minutes
Nix Ultra All-in-Once Shampoo Laureth-4 Mineral oil MPA-laureth sulfate
  • Kills superlice and eggs
  • Applied for 10 minutes
  • Safe for people 1 year and older
  • Pesticide-free
RID Lice Killing Shampoo Piperonyl butoxide Pyrethrum extract
  • Shampoo and conditioner in one
  • No chemical residue
Vamousse Lice Treatment Sodium chloride
  • Homeopathic
  • Kills super lice and eggs
  • Pesticide-free
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.