Best OTC Drugs 2024

Best OTC Choices in Menstrual Pain Relief

Money’s list of the best choices to relieve pain during menstruation includes several types. There are familiar names in diverse pain relief, a longtime specialty menstrual pain product and a Transcutaneous Electrical Nerve Stimulation machine that some say delivers relief through electronic pulses delivered through the skin.

The selections were made by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Advil Ibuprofen
  • Treats menstrual cramps
  • Available in tablets and capsules
  • Can take every 4-6 hours
  • Can cause upset stomach
Aleve Liquid Gels Naproxen
  • Treats menstrual cramps
  • Lasts 12 hours
  • Capsules
  • Can cause stomach upset
Midol Complete Acetaminophen Caffeine Pyrilamine
  • Available as tablets and capsules
  • Lasts up to 6 hours
  • Relieves cramps and bloating
Motrin Liquid Gels Ibuprofen
  • Treats menstrual cramps
  • Capsules
  • Can take every 4-6 hours
  • Can cause upset stomach
Omron TENS N/A
  • Drug-free
  • Adjustable levels of intensity
  • Can use as needed
Pamprin Multi-Symptom Acetaminophen Pamabrom Pyrilamine
  • Tablets
  • Can take every 6 hours
  • Relieves cramps and bloating
Thermacare Menstrual Heat Wraps N/A
  • Drug-free
  • Works up to 8 hours
  • Relieves menstrual cramps
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.