Best OTC Drugs 2024

Best OTC Choices in Therapeutic Skin Care, Moisturizers

The best therapeutic moisturizers can not only improve the signs and symptoms of dry skin but maintain the skin’s hydration and overall integrity. Here are Money’s picks for the best over-the-counter therapeutic skin-care moisturizers.

The selections were chosen by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Aquaphor Healing Ointment Petrolatum
  • Preservative-free
  • Fragrance-free
  • Protects and treats chapped skin and lips
Aveeno Skin Relief Moisture Repair Cream Glycerin Petrolatum Dimethicone Avena sativa kernel flour Avena sativa kernel oil Ceramide NP Shea butter
  • Can apply as needed
  • Can be used on the body
  • Rich cream
CeraVe Moisturizing Cream Cetearyl alcohol Petrolatum Ceramide NP Ceramide AP Ceramide EOP Dimethicone
  • Helps restore protective skin barrier
  • Fragrance-free
  • Non-greasy
Cetaphil Moisturizing Cream Glycerin Petrolatum Dimethicone Sunflower seed oil
  • 48-hour hydration
  • Fragrance-free
  • Paraben-free
Cetaphil Restoraderm Eczema Soothing Moisturizer Colloidal oatmeal
  • Applied as needed
  • Fragrance-free
  • Paraben-free
Derma E Psorzema Cream Glycerin Dimethicone
  • Can apply as needed
  • Vegan
  • Contains herbal extracts
Eucerin Advanced Repair Cream Glycerin Urea Ceramide NP
  • Fragrance-free
  • Safe for people 5 years and older
  • Helps prevent dry skin
La Roche-Posay Lipikar Balm AP+ Intense Repair Moisturizing Cream Shea butter Glycerin Dimethicone Cetearyl alcohol Niacinamide Ceramide NP
  • Safe for people 2 weeks and older
  • Dermatologist-tested
  • 48-hour hydration
Neutrogena Hydro Boost Water Gel Hyaluronic acid
  • Oil-free
  • Can be used under makeup
  • Non-comedogenic
Vanicream Moisturizing Cream Petrolatum Cetearyl alcohol
  • Non-greasy
  • Fragrance-free
  • Can apply to face and body
  • Can use as needed
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.