Best OTC Drugs 2024

Best OTC Choices in Topical Poison Ivy/Oak Remedies

While the rash from poisonous plants usually goes away on its own within a week or two, over-the-counter medications can relieve the itchiness and discomfort of that period. Here are Money’s picks for the best topical remedies for poison ivy and poison oak.

The selections were identified by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Aveeno Soothing Bath Treatment Colloidal oatmeal
  • Relieves dry, itchy skin
  • Fragrance-free
  • Used in a bath
Burt's Bees Poison Ivy Soap Kaolin Avena sativa protein extract Tea tree leaf oil Pine wood tar Jewelweed leaf extract
  • Used to wash skin 2-3 times a day
  • Soap bar
  • Preservative-free
Cortizone-10 Maximum Strength Anti-Itch Cream Hydrocortisone
  • Fragrance-free
  • Dye-free
  • Relieves itching
Domeboro Astringent Solution Powder Packets Aluminum sulfate tetradecahydrate Calcium acetate monohydrate
  • Fast relief
  • Relieves itching and burning skin
  • Used to soak skin
Gold Bond Rapid Relief Anti-Itch Cream Menthol Pramoxine
  • Steroid-free
  • Relieves pain and itching
  • Cream
  • Fast-acting
IvyX Post-Contact Skin Cleanser Petrolatum oil Triethanolamine Carbomer
  • Removes urushiol
  • Contains moisturizers
Tecnu Extreme Poison Ivy and Oak Scrub Polyoxyethylene lauryl ether Polysorbate 20 Alcohol Silicon dioxide Carbomer Grindelia robusta extract Benzethonium chloride Aminomethyl propanol
  • Removes oils in 15 seconds
  • Should use within 8 hours of exposure
Walgreens Calamine Lotion Calamine Zinc oxide
  • Dries oozing and weeping
  • Can be applied as needed
Zanfel Poison Ivy, Oak & Sumac Wash Polyethylene granules Sodium lauroyl aarcosinate Nonoxynol-9 C12-15 pareth-9 Disodium EDTA Quaternium-15 Carbomer Triethanolamine
  • Fast-acting
  • Can be used on the face or body
  • Removes urushiol
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.