Best OTC Drugs 2024

Best OTC Choices in Upset Stomach Remedies

Products to remedy an upset stomach range from those that reduce the amount of acid in your stomach to those known for addressing motion sickness and nausea.

Here are Money’s picks for the best upset stomach remedies, along with information on their active ingredients and general notes about efficacy and side effects.

These products were selected by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Alka-Seltzer Anhydrous citric acid Aspirin Sodium bicarbonate
  • Effervescent tablets
  • Safe in people 12 years and older
  • Relieves heartburn, upset stomach, and indigestion with headache and body aches
Dramamine Dimenhydrinate
  • Safe in people 2 years and older
  • Can help prevent motion sickenss
  • Tablets
Emetrol Nausea Relief Liquid Dextrose Levulose Phosphoric acid
  • Non-drowsy
  • Safe for people 2 years and older
  • Cherry flavor
Gas-X Extra Strength Chewables Simethicone
  • Chewable tablets
  • Taken as needed after meals and at bedtime
  • Safe for people 12 years and older
Gin Gins Original Ginger Chews Ginger
  • Chews
  • Vegan
  • Contains sugar
  • Gluten-free
Imodium A-D Loperamide
  • Controls diarrhea
  • Safe for people 6 years and older
  • Available as pills and liquid
Pepto-Bismol Bismuth subsalicylate
  • Liquid
  • Safe for people 12 years and older
  • Relieves upset stomach, diarrhea, heartburn, and nausea
Tums Extra Strength Calcium carbonate
  • Works fast to relieve heartburn
  • Safe for people 12 years and older
  • Chewable tablets
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.