TrumpRx Adds Hundreds of Drugs to Discount Site. Are Your Prescriptions on the List?

The White House’s direct-to-consumer prescription drug website TrumpRx.gov, which launched in February, recently announced two significant expansions. President Donald Trump said last week that 160 additional prescription medications would be added to the platform in a post on Truth Social. The news came just a few weeks after a May event at the White House announcing that TrumpRx would add 600 generic medications.

Although the direct-to-consumer model is new for the federal government, the concept of a middleman that delivers prescription drug savings to consumers isn’t groundbreaking: GoodRx.com has been around for 15 years, offering comparison-shopping, coupon codes and a subscription-based model for deeper discounts through partnerships with pharmacy benefit managers.

And in 2022, entrepreneur Mark Cuban of Shark Tank fame launched the Mark Cuban Cost Plus Drug Co. The MCCPDC website, CostPlusDrugs.com, gives people access to low-cost generic drugs and uses a transparent fee structure. TrumpRx's expansion into generics comes via partnerships with Cost Plus Drugs and GoodRx, as well as Amazon Pharmacy.

TrumpRx was modest in scope initially, with discounts available on just 43 drugs, primarily weight-loss and fertility medications, so these recent announcements mark a significant expansion of the platform. The White House has touted the initiative as a push to lower costs and increase transparency in the notoriously complex pharmaceutical marketplace.

The industry is taking it seriously.

"The site's "coverage footprint... could place the platform squarely inside the everyday prescription experience of many cash-paying American patients," an article in trade publication Pharmaceutical Commerce observed.

The implications could be major, the article warned, forcing the industry to be more transparent and straightforward about how drugs are priced.

"Pricing benchmarks also become more visible and more consequential... Patient expectations around what a drug should cost could begin to anchor around those figures, creating internal pressure on manufacturers to rationalize" the myriad — and often wildly different — prices patients have to navigate today.

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What common medications are on the TrumpRx platform?

The recently announced expansions, particularly the incorporation of hundreds of generic drugs, makes it likelier that more of the prescriptions Americans take on a daily basis will be covered. The government does note that TrumpRx doesn't cover controlled substances, medications not typically offered via direct-to-consumer channels or that are currently undergoing certain types of FDA evaluation.

Below were the top 10 most-frequently prescribed drugs in 2025, according to analytics firm Definitive Healthcare. They include common remedies for cardiovascular, thyroid and nerve conditions, among others. All are listed on TrumpRx via one or more of its partners.

1. Atorvastin (Lipitor)
2. Amlodipine besylate (Norvasc)
3. Levothyroxine sodium (Synthroid)
4. Lisinopril (Zestril, Prinivil)
5. Gabapentin (Neurontin, Gralise)
6. Losartan potassium (Cozaar)
7. Omeprazole (Prilosec)
8. Amoxicillin (Augmentin)
9. Metformin (Glucophage)
10. Sertraline (Zoloft)

Will TrumpRx make your medicine cheaper?

The short answer is “maybe”; the slightly longer answer is “it depends.” The upshot is that getting to the bottom of that question involves factoring in a lot of moving parts, and looking at your health care and prescription spending holistically.

TrumpRx doesn’t actually sell drugs, as the site’s FAQ explains. Instead, it directs customers to manufacturers’ own savings programs or to participating pharmacies where shoppers can use coupon codes that TrumpRx provides.

But TrumpRx isn't the only place patients can go for deals. In addition to sites like CostPlusDrugs and GoodRx, some pharmaceutical companies, like Eli Lilly, have their own direct-to-consumer online storefronts where customers can access discounts.

For starters, people who have insurance aren’t likely to save money using TrumpRx. Most insurance co-pays for prescriptions are lower than the self-pay prices, even at a discount. The site acknowledges this, prompting users to check their insurance coverage first. What's more, the out-of-pocket costs you pay don't count toward your health insurance deductible.

Many of the discounts displayed are hefty, ranging from 33% to 93% off. But these percentages are based on original list prices that few, if any, customers would actually pay after insurance- and pharmacy-negotiated discounts are factored in.

"For... most brand-name medications, people are likely to get a better deal using their insurance rather than purchasing a drug through a direct-to-consumer website,” Juliette Cubanski, the deputy director of research organization KFF's program on Medicare Policy, told CNBC in February.

Some of the expensive name-brand medications on the TrumpRx site are already available in generic versions that are cheaper than the discounted name-brand drugs on TrumpRx.

In addition, it’s important to read the fine print; some of the discounted prices on TrumpRx are only for an initial course of the drug — say, the first month of treatment — after which the price rises. And the discounted prices advertised are, in some cases, temporary promotions.

For popular drugs such as Ozempic and Wegovy, which insurance doesn't often cover — or covers for a limited time or only for certain conditions (such as diabetes or sleep apnea) — TrumpRx may save you money. But again, there are other factors to consider.

For instance, in some cases, self-paying customers might be able to get discounts or coupons directly from the drugmaker. (It's a good idea to check the manufacturer’s website first if you need an expensive prescription not covered by insurance.)

If you choose to self-pay rather than go through your insurance, your purchases might not count toward your deductible or out-of-pocket maximum. This is also a drawback with using GoodRx, MCCPDC and other direct-to-consumer sites, although a recent settlement reached between the Federal Trade Commission and pharmacy benefit manager Express Scripts could pave the way for direct-pay drug purchases to count toward these thresholds in the future.

The bottom line? Don’t assume TrumpRx will give you the best deal on drug prices. “There may be patients who think this is a good deal and then end up financially worse off,” Rachel Sachs, a law professor who studies drug pricing at Washington University in St. Louis, told the Times.

While it’s smart to include TrumpRx on the list of sites you check when comparison-shopping for prescriptions, ultimately, it might not make much of a difference in your medication expenses.

For many Americans, it's more likely that adding one more platform to the already-complex prescription drug marketplace will make the hunt for cheaper meds more complicated.