Best OTC Drugs 2024

Best OTC Choices in Probiotic Dietary Supplements

Probiotics are substances you ingest that contain live microorganisms intended to maintain or improve the "good" bacteria (normal microflora) in the body. While there’s no consensus that ingesting probiotics through supplements — usually in capsule form — boosts health, a range of such products are available.

Here are Money’s picks for the best probiotic dietary supplements, along with general information on their active ingredients and more.

These products were selected by drugs.com, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on Money.com is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Rank
Medication
Active Ingredients
Important Points
#5
Align Digestive Support Bifidobacterium longum
  • Capsules
  • Taken once a day
#1
Culturelle Ultimate Strength Probiotic Lactobacillus rhamnosus Inulin
  • Capsules
  • Taken once a day
#10
Dr. Mercola Complete Probiotics Lactobacillus acidophilus Bifidobacterium lactis Lactobacillus plantarum Lactobacillus casei Lactobacillus rhamnosus Lactobacillus brevi Bifidobacterium bifidum Bifidobacterium longum Lactobacillus salivarius Streptococcus thermophilus
  • Capsules
  • For adults only
  • Taken once a day
#8
Florastor Daily Probiotic Supplement Saccharomyces boulardii
  • Capsules
  • Taken 1-2 times daily
#3
Garden of Life Raw Probiotics Ultimate Care ISS Bif™ Bifdobacterium lactis (SD-5219) Lactobacillus acidophilus (SD-5221) Lactobacillus paracasei (SD-5218) Bifidobacterium lactis (SD-5220) Bulgarian Yogurt (milk) concentrate Eastern European Wild Kefir Culture containing Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, lacotbacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum, Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris, Streptococcus thermophilus, Lactobacilus kefir, Lactobacillus parakefir, Lactobacillus plantarum, Lactococcus lactis biovar diacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromyces marxianus, Brettanomyces anomalus, Debaryomyces hansenii, Saccharomyces unisporus, Saccharomyces turicensis, Saccharomyces cerevisiae, Saccharmomyces exiguus, Torulaspora delbrueckii Protease Acid protease Protease S Eastern European RAW Fruit and Veggie Blend
  • Capsules
  • For adults only
  • Taken once a day
  • Can take with or without food
#6
MegaFood Probiotic Bifidobacterium lactis Lactobacillus acidophilus Lactobacillus casei Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus salivarius Lactobacillus brevis Lactobacillus bulgaricus Lactobacillus gasseri Lactobacillus lactis Bifidobacterium longum Bifidobacterium bifidum Bifidobacterium infantis Streptococcus thermophilus
  • Capsules
  • Taken once a day with food
  • For adults only
#9
Nature's Way Probiotic Pearls Complete Digestive Health Lactobacillus acidophilus Lactobacillus rhamnosus Bifidobacterium bifidum Bifidobacterium longum
  • Capsules
  • For adults only
  • Can take with or without food
#4
NOW Foods Probiotic-10 Lactobacillus acidophilus Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus casei Lactobacillus paracasei Streptococcus thermophilus Bifidobacterium lactis Bifidobacterium longum Bifidobacterium breve Lactobacillus salivarius
  • Capsules
  • Taken once daily
  • Take on an empty stomach
#2
Renew Life Everyday Probiotic Bifidobacterium lactis Bifidobacterium infantis Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus acidophilus Lactobacillus lactis Lactobacillus casei Lactobacillus paracasei Lactobacillus brevis
  • Capsules
  • Gluten-free
#7
VSL#3 Streptococcus thermophilus Bifidobacterium breve Bifidobacterium longum (reclassified as B. lactis) Bifidobacterium infantis (reclassified as B. lactis) Lactobacillus acidophilus Lactobacillus plantarum Lactobacillus paracasei Lactobacillus delbrueckii subsp. bulgaricus
  • Capsules
  • For adults and children
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