Best OTC Drugs 2024

Best OTC Choices in Topical Anesthetics (not oral)

Applying an over-the-counter anesthetic can offer relief from a burn, bite or other minor injury. Here are Money’s picks for the best anesthetics to apply topically, along with data on their active ingredients and general notes about their efficacy and side effects.

The selections were chosen by, using a methodology that combines expert assessment with analysis of online reviews, ratings and other customer data.

The information provided on is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. The products featured may not be right for everyone and may carry risk even if available without a prescription. Read the product’s label and consult with a professional for individual medical advice.

Slide Table to Compare
Active Ingredients
Important Points
Anesten Cream Lidocaine
  • Should apply 1 to 1.5 hours before tattoo
  • Not for use around eyes
  • Water-based
Bactine Max Pain Relieving Cleansing Spray Benzalkonium Cl Lidocaine
  • Fast relief of burns
  • Safe for people 2 years and older
  • Can use up to 4 times a day
Ebanel Numb 520 Lidocaine
  • Local and anorectal use
  • Works in 5 minutes
  • Fragrance-free
  • Non-greasy
HUSH Gel Lidocaine Aloe leaf extract Calendula extract Chamomile extract Green tea extract Comfrey extract Menthol
  • Must allow 1 hour for absorption
  • Used for numbing before tattoo
Lanacane Medicated cream Benzocaine
  • Fast-acting
  • Cream
Numb Master Numbing cream Lidocaine
  • Works in 5 minutes
  • Non-greasy
  • Fragrance-free
Numbskin Numbing cream Lidocaine
  • Fast-acting
  • Cream
Vasocaine Lidocaine
  • Fast-acting
  • Spray
No results match.

Featured drugs are available without a prescription in the U.S. and may not be available with or without a prescription in other locations.